Reduced expression and rare genomic alteration of nm23-H1 in human hepatocellular carcinoma and hepatoma cell lines.

doi:10.1007/s005350050098

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Article

Reduced expression and rare genomic alteration of nm23-H1 in human hepatocellular carcinoma and hepatoma cell lines.

Journal of gastroenterology - 1 Jun 1998

Fujimoto Y, Ohtake T, Nishimori H, Ikuta K, Ohhira M, Ono M, Kohgo Y

Abstract excerpt

We investigated the expression and genomic alteration of nm23-H1 (which encodes a nucleoside diphosphate, kinase A) in 12 human hepatocellular carcinomas (HCCs) and four hepatoma cell lines. The expression of nm23-H1 protein was significantly reduced in HCCs with intrahepatic metastasis (72%) com...

Topics

Adult
Aged
Biomarkers, Tumor
Blotting, Northern
Blotting, Western
Carcinoma, Hepatocellular
DNA Primers
Down-Regulation
Exons
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Liver Neoplasms
Male
Microsatellite Repeats
Middle Aged
Monomeric GTP-Binding Proteins

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PMID: 9658316
DOI: 10.1007/s005350050098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9658316-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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