Article
Analysis of chromosome 22 loci in meningioma. Alterations in the leukemia inhibitory factor (LIF) locus.
Molecular and chemical neuropathology - 1 Jan 2000
Pergolizzi R G, Erster S H
Abstract excerpt
Meningiomas are typically benign tumors arising from arachnoidal cells at the base of the brain. Meningioma is thought to result from the loss or inactivation of a putative tumor suppressor gene located on chromosome 22. We analyzed a set of meningioma DNA specimens by Southern blot hybridization...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Base Sequence
- Cell Differentiation
- Cell Division
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, Pair 22
- DNA Primers
- DNA, Neoplasm
- Exons
- Female
- Genes, Recessive
- Genes, Tumor Suppressor
- Genetic Markers
- Growth Inhibitors