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Article

Frequent loss of 1p32 region but no mutation of the p18 tumor suppressor gene in meningiomas.

Journal of neuro-oncology - 1 Dec 2000

Leuraud P, Marie Y, Robin E, Huguet S, He J, Mokhtari K, Cornu P, Hoang-Xuan K, Sanson M

Abstract excerpt

After chromosome 22 and NF2 inactivation, the loss of chromosome 1p is one of the most frequent abnormalities encountered in meningiomas. However the putative tumor suppressor gene located on 1p inactivated in meningiomas has still to be identified. We screened 68 meningiomas for LOH on chromosome 22 and 1. We found 34 LOH on the NF2 region on chromosome 22 (50%) and 19 LOH on 1p (28%), 16 being associated with...

Topics

Alleles
Blotting, Southern
Carrier Proteins
Cell Cycle Proteins
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 22
Cyclin-Dependent Kinase Inhibitor p18
Cyclin-Dependent Kinases
DNA Primers
Enzyme Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Deletion

Genes, Tumor Suppressor

Homozygote

Humans

Loss of Heterozygosity

Meningeal Neoplasms

Meningioma

Microsatellite Repeats

Source

Identifiers

PMID: 11263500
DOI: 10.1023/a:1006400723490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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