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Article

Loss of heterozygosity analysis of benign, atypical, and anaplastic meningiomas.

Neurosurgery - 1 Nov 2004

Lee John Y K, Finkelstein Sydney, Hamilton Ronald L, Rekha Rapaka, King Joseph T, Omalu Bennett

Abstract excerpt

OBJECTIVE: Up to 70% of typical meningiomas demonstrate allelic loss at chromosome 22q. Allelic loss at additional chromosomal loci is associated with atypia and anaplasia in meningiomas. The pattern of allelic loss or loss of heterozygosity (LOH) follows a nonrandom, multistep pattern. METHODS: All surgical meningioma samples obtained from 1991 to 1992 at the University of Pittsburgh Medical Center were analyzed...

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PMID: 15509323
DOI: 10.1227/01.neu.0000141081.07086.a0

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