Insulin gene 5' flanking polymorphism. Length of class 1 alleles in number of repeat units.

doi:10.2337/diab.44.11.1296

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Article

Insulin gene 5' flanking polymorphism. Length of class 1 alleles in number of repeat units.

Diabetes - 1 Nov 1995

McGinnis R E, Spielman R S

Abstract excerpt

The 5' flanking polymorphism (5'FP) is a minisatellite, variable number of tandem repeat (VNTR) locus adjacent to the 5' end of the insulin gene (INS). Alleles of the 5'FP are highly variable in length but fall into three discrete size classes. The shortest, or class 1, alleles are associated with insulin-dependent diabetes mellitus (IDDM). Here we present a polymerase chain reaction (PCR)-based technique for...

Topics

Adult
Alleles
Base Sequence
Blotting, Southern
Child
Consensus Sequence
DNA Primers
DNA, Satellite
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus, Type 1
Female
Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genetic Variation

Genotype

Haplotypes

Humans

Insulin

Source

Open in PubMed

Identifiers

PMID: 7589827
DOI: 10.2337/diab.44.11.1296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7589827-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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