Article
Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains.
AIDS (London, England) - 23 Nov 2001
Goudsmit J, Weverling G J, van der Hoek L, de Ronde A, Miedema F, Coutinho R A, Lange J M, Boerlijst M C
Abstract excerpt
OBJECTIVE: Because maintenance of treatment success in HIV-1 infection requires viruses to remain therapy sensitive in drug-naive seropositive persons, we looked at the primary infections caused by drug-resistant HIV-1 over time. Furthermore, to study the coverage rate of therapy and therapy failure in relation to the transmission of resistant viruses a mathematical model was developed. DESIGN: The reverse...
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