Loss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis.

Article

Loss of Na+ channel inactivation by anemone toxin (ATX II) mimics the myotonic state in hyperkalaemic periodic paralysis.

The Journal of physiology - 1 Jul 1993

Cannon S C, Corey D P

Abstract excerpt

1. Mutations that impair inactivation of the sodium channel in skeletal muscle have recently been postulated to cause several heritable forms of myotonia in man. A peptide toxin from Anemonia sulcata (ATX II) selectively disrupts the inactivation mechanism of sodium channels in a way that mimics...

Topics

Action Potentials
Animals
Cnidarian Venoms
Disease Models, Animal
Female
Humans
Hyperkalemia
In Vitro Techniques
Isometric Contraction
Muscles
Mutation
Myotonia
Paralyses, Familial Periodic
Rats
Sea Anemones
Sodium Channel Blockers
Sodium Channels

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