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Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8<sup>+</sup>-T-Lymphocyte Responses

13 Feb 2004

Abstract excerpt

The speed of virus replication has typically been seen as an advantage for a virus in overcoming the ability of the immune system to control its population growth. Under some circumstances, the converse may also be true: more slowly replicating viruses may evoke weaker cellular immune responses and therefore enhance their likelihood of persistence. Using the model of lymphocytic choriomeningitis virus (LCMV)...

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PMID: 14963121
DOI: 10.1128/jvi.78.5.2247-2254.2004

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