Article
T-cell receptor constant beta germline gene polymorphisms and susceptibility to autoimmune hepatitis.
Gastroenterology - 1 May 1994
Manabe K, Hibberd M L, Donaldson P T, Underhill J A, Doherty D G, Demaine A G, Mieli-Vergani G, Eddleston A L, Williams R
Abstract excerpt
BACKGROUND/AIMS: Susceptibility to autoimmune hepatitis is associated with HLA A1-B8-DR3 and DR4. T-Cell antigen receptors (TCR) are candidates for genetic susceptibility to autoimmune diseases because they recognize peptide antigens in the context of HLA molecules. The aim of this study was to i...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Autoimmune Diseases
- Child
- Child, Preschool
- DNA
- Female
- Genetic Predisposition to Disease
- Genotype
- HLA-A1 Antigen
- HLA-B8 Antigen
- HLA-DR3 Antigen
- HLA-DR4 Antigen
- Hepatitis
- Homozygote