Article
Distribution of HLA-DQA1, -DQB1 and DRB1 alleles in black IDDM patients and controls from Zimbabwe.
Tissue antigens - 1 Sept 1992
Garcia-Pacheco J M, Herbut B, Cutbush S, Hitman G A, Zhonglin W, Magzoub M, Bottazzo G F, Kiere C, West G, Mvere D
Abstract excerpt
We have used the XI Histocompatibility Workshop sequence-specific oligonucleotide probes to determine the DRB1, DQA1 and DQB1 genotypes by dot-blot hybridization of polymerase chain reaction (pcr)-amplified material from a homogenous black population in Zimbabwe. The DR4 subtype DRB1*0405, the DR...
Topics
- Adult
- Alleles
- Black People
- Child
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Gene Frequency
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Antigens Class II