Article
Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to lung cancer.
Japanese journal of cancer research : Gann - 1 Mar 1991
Uematsu F, Kikuchi H, Motomiya M, Abe T, Sagami I, Ohmachi T, Wakui A, Kanamaru R, Watanabe M
Abstract excerpt
Cytochrome P450IIE1 (P450IIE1) is involved in metabolic activation of carcinogenic nitrosamines, aniline and benzene. We detected a restriction fragment length polymorphism of the human P450IIE1 gene with the restriction endonuclease DraI. The population was thus divided into three genotypes, nam...
Topics
- Adenocarcinoma
- Biomarkers, Tumor
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Exons
- Genes
- Genetic Carrier Screening
- Genetic Predisposition to Disease