Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis.

doi:10.1016/0270-9139(95)90621-5

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Article

Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis.

Hepatology (Baltimore, Md.) - 1 Oct 1995

Yamauchi M, Maezawa Y, Mizuhara Y, Ohata M, Hirakawa J, Nakajima H, Toda G

Abstract excerpt

Alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and P450IIE1 are the primary enzymes that catalyze the conversion of ethanol to acetaldehyde and then to acetate. Genetic polymorphisms have been reported in ADH2, ADH3, ALDH2, and the 5'-flanking region of P450IIEI. In this study, we us...

Topics

Adult
Aged
Alcohol Dehydrogenase
Aldehyde Dehydrogenase
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme System
Deoxyribonucleases, Type II Site-Specific
Genotype
Humans
Japan
Liver Cirrhosis, Alcoholic
Male
Middle Aged
Multivariate Analysis
Oxidoreductases, N-Demethylating
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 7557863
DOI: 10.1016/0270-9139(95)90621-5

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7557863-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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