Article
Blood T-cell receptor diversity decreases during the course of HIV infection, but the potential for a diverse repertoire persists.
Blood - 12 Apr 2012
Baum Paul D, Young Jennifer J, Schmidt Diane, Zhang Qianjun, Hoh Rebecca, Busch Michael, Martin Jeffrey, Deeks Steven, McCune Joseph M
Abstract excerpt
HIV infection results in a decrease in circulating CD4(+) T-cell and naive T-cell numbers. If such losses were associated with an erosion of T-cell receptor (TCR) repertoire diversity in the peripheral T-cell pool, this might exacerbate the state of persistent immunodeficiency. Existing methods for the analysis of the TCR repertoire have demonstrated skewed distributions of TCR genes in HIV-infected subjects but...
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