Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

15 Feb 2019

Abstract excerpt

Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease. However, a major limitation of this approach in quiescent adult primary hepatocytes is that nonhomologous end‐joining is the predominant DNA repair pathway for double‐strand breaks (DSBs). This study explored the hypothesis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to Renal Transplantation Outcomes and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30976745
DOI: 10.1002/hep4.1315

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After TransplantationPMID 30976745Read ↗

Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1Semantic proximity Read ↗

EX VIVO GENE EDITING AND CELL THERAPY FOR HEREDITARY TYROSINEMIA TYPE 1Semantic proximity Read ↗

A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factorsSemantic proximity Read ↗

Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cellsSemantic proximity Read ↗

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human LiverSemantic proximity Read ↗

<i>Ex Vivo</i> Hepatic Gene Therapy of a Mouse Model of Hereditary Tyrosinemia Type ISemantic proximity Read ↗

Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells.Semantic proximity Read ↗

A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver.Semantic proximity Read ↗

<i>In vivo</i> expansion of gene-targeted hepatocytes through transient inhibition of an essential geneSemantic proximity Read ↗

Advancements in Disease Modeling and Drug Discovery Using iPSC-Derived Hepatocyte-like CellsSemantic proximity Read ↗

Adeno‐associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo†‡Semantic proximity Read ↗

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.