Article
CD4 negative mice as a model for immunodeficiency.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Oct 1993
Rahemtulla A, Shahinian A, Kundig T, Zinkernagel R, Mak T W
Abstract excerpt
CD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells h...
Topics
- Animals
- Antibody Formation
- CD4 Antigens
- CD8 Antigens
- Disease Models, Animal
- Immunologic Deficiency Syndromes
- Lymph Nodes
- Mice
- Mice, Mutant Strains
- Phenotype
- T-Lymphocyte Subsets
- T-Lymphocytes