Article
CD4 negative mice as a model for immunodeficiency.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Oct 1993
Rahemtulla A, Shahinian A, Kundig T, Zinkernagel R, Mak T W
Abstract excerpt
CD4 is a co-receptor required for T cell helper functions. A mouse strain without CD4 expression has been generated. These animals, surprisingly have a normal CTL response and reduced, but not absent, humoral responses. A new population of MHC class II restricted CD4-CD8-TcR alpha beta+ T cells has emerged which possess helper function potential. These findings have important implications on disease situations...
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