Article
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice.
Science (New York, N.Y.) - 10 Sept 1993
Locksley R M, Reiner S L, Hatam F, Littman D R, Killeen N
Abstract excerpt
Expression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes. A null mutation in the gene encoding CD4 impairs the development of the helper cell lineage that is normally defined by CD4 expression. Infection of CD4-null mice with Leishmania has revealed a population of functional helper T cells that develops despite the absence of CD4. These CD8- alpha beta T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.