Article
Genetic analysis of systemic lupus erythematosus: association with a T cell receptor restriction fragment length polymorphism in Japanese patients.
Internal medicine (Tokyo, Japan) - 1 Aug 1992
Morito F, Hiida M, Ohta A, Yamaguchi M
Abstract excerpt
Many studies have suggested the involvement of multiple genetic loci in the development of systemic lupus erythematosus (SLE). We have analyzed the correlation between various genetic markers and the susceptibility to SLE. In this study, the association of SLE and restriction fragment length polymorphism (RFLP) of T cell receptor gene was evaluated. The cDNA for constant regions of alpha, beta and gamma chain...
Topics
- Blotting, Southern
- DNA
- Female
- Genotype
- Humans
- Japan
- Lupus Erythematosus, Systemic
- Male
- Pedigree
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell