Article
RFLP analysis in the TNF-beta gene and the susceptibility to alloreactive NK cells in Behçet's disease.
Investigative ophthalmology & visual science - 1 Oct 1992
Mizuki N, Inoko H, Sugimura K, Nishimura K, Nakamura S, Tanaka H, Mizuki N, Mizuki H, Inaba G, Tsuji K
Abstract excerpt
Behçet's disease is known to be associated with HLA-B51. To address the possibility that a non-human leukocyte antigen (HLA) gene closely linked to the HLA-B gene, such as tumor necrosis factor (TNF)-alpha, TNF-beta, or ECl (the locus that determines the susceptibility to alloreactive natural killer [NK] cells), is involved in the susceptibility to Behçet's disease, NcoI and EcoRI restriction fragment length...
Topics
- Base Sequence
- Behcet Syndrome
- Blotting, Southern
- Cytotoxicity, Immunologic
- DNA
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-B Antigens
- Humans
- Killer Cells, Natural