Article
Wildtype p53-specific antibody and T-cell responses in cancer patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Pedersen Anders Elm, Stryhn Anette, Justesen Sune, Harndahl Mikkel, Rasmussen Susanne, Donskov Frede, Claesson Mogens H, Pedersen Johannes W, Wandall Hans H, Svane Inge Marie, Buus Søren
Abstract excerpt
Mutation in the p53 gene based on single amino acid substitutions is a frequent event in human cancer. Accumulated mutant p53 protein is released to antigen presenting cells of the immune system and anti-p53 immune responses even against wt p53 is induced and observed in a number of human cancer patients. Detection of antibodies against wt p53 protein has been used as a diagnostic and prognostic marker and...
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