Article
A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
International journal of cancer - 15 Aug 1994
Fossum B, Breivik J, Meling G I, Gedde-Dahl T, Hansen T, Knutsen I, Rognum T O, Thorsby E, Gaudernack G
Abstract excerpt
We have characterized and described in detail 2 CD4+ T-lymphocyte clones (TLC) from a colonic cancer patient. These TLC specifically recognize a K-ras-derived peptide carrying the 13Asp mutation commonly found in adenocarcinomas of the colon. The TLC were independently derived, as they carried 2...
Topics
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- Colorectal Neoplasms
- Conserved Sequence
- Female
- Genes, ras
- HLA-DQ Antigens
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutation