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Article

In vitro comparison of the effect of two factor XI (FXI) concentrates on thrombin generation in major FXI deficiency.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2016

Pike G N, Cumming A M, Hay C R M, Sempasa B, Sutherland M, Thachil J, Burthem J, Bolton-Maggs P H B

Abstract excerpt

INTRODUCTION: Bleeding risk in factor XI (FXI) deficiency following surgery may be reduced by treatment with either of two FXI concentrates, but indications for their use are unclear and treatment has been associated with thrombosis. AIM: To quantify and compare the effects of two different FXI concentrates on thrombin generation (TG) in major FXI deficiency (FXI:C < 15 IU dL(-1) ). METHODS: Thrombin generation...

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PMID: 26558335
DOI: 10.1111/hae.12846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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