Article
Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene.
Oncogene - 2 Mar 1995
Fujiwara Y, Ohata H, Kuroki T, Koyama K, Tsuchiya E, Monden M, Nakamura Y
Abstract excerpt
We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears si...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Hepatocellular
- Carcinoma, Non-Small-Cell Lung
- Chromosomes, Human, Pair 8
- Colorectal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Liver Neoplasms
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Receptors, Platelet-Derived Growth Factor