Quantification of the mononuclear phagocyte response to Wallerian degeneration of the optic nerve.

doi:10.1007/BF01268086

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Article

Quantification of the mononuclear phagocyte response to Wallerian degeneration of the optic nerve.

Journal of neurocytology - 1 Dec 1994

Lawson L J, Frost L, Risbridger J, Fearn S, Perry V H

Abstract excerpt

We investigated the numbers, origin and phenotype of mononuclear phagocytes (macrophages/microglia) responding to Wallerian degeneration of the mouse optic nerve in order to compare it with the response to Wallerian degeneration in the PNS, already described. We found macrophage/microglial numbers elevated nearly four fold in the distal segments of crushed optic nerves and their projection areas in the...

Topics

Analysis of Variance
Animals
Antibodies, Monoclonal
Axons
Cell Survival
Female
Histocompatibility Antigens Class II
Immunohistochemistry
Macrophage-1 Antigen
Macrophages
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Neurologic Mutants

Microglia

Necrosis

Nerve Crush

Optic Nerve

Source

Open in PubMed

Identifiers

PMID: 7897440
DOI: 10.1007/BF01268086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7897440-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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