Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype.

Investigative ophthalmology & visual science - 1 Feb 2017

Wang Rui, Seifert Philip, Jakobs Tatjana C

Abstract excerpt

Purpose: Optic nerve head astrocytes, a subtype of white-matter astrocytes, become reactive early in the course of glaucoma. It was shown recently that in the DBA/2J mouse model of inherited glaucoma optic nerve astrocytes extend new longitudinal processes into the axon bundles before ganglion cell loss becomes apparent. The present study aims at testing whether this behavior of astrocytes is typical of early...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Glaucoma
Share to Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Image Processing, Computer-Assisted

Share to Intraocular Pressure

Share to Mice, Inbred DBA

Share to Microscopy, Electron, Transmission

Share to Optic Disk

Source

Open in PubMed Open full text

Identifiers

PMID: 28170536
DOI: 10.1167/iovs.16-20571
PMCID: PMC5300248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype.PMID 28170536Read ↗

The Dual Role of Macroglia in Glaucoma: Deciphering the Contributions of Astrocytes and Müller Cells to Retinal Neurodegeneration and NeuroprotectionSemantic proximity Read ↗

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.Semantic proximity Read ↗

Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Experimental Glaucoma and Optic Nerve CrushSemantic proximity Read ↗

Individual Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic LabelingSemantic proximity Read ↗

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.Semantic proximity Read ↗

Myocilin expression in the astrocytes of the optic nerve head.Semantic proximity Read ↗

Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development.Semantic proximity Read ↗

Microglia respond to elevated intraocular pressure and synapse loss in the visual thalamus in a mouse model of glaucomaSemantic proximity Read ↗

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathySemantic proximity Read ↗

Development of Retinal AstrogliaSemantic proximity Read ↗

Platelet-derived growth factor-A-induced retinal gliosis protects against ischemic retinopathy.Semantic proximity Read ↗

Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.