Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury.

BMC neuroscience - 6 Jun 2012

Lorber Barbara, Tassoni Alessia, Bull Natalie D, Moschos Marilita M, Martin Keith R

Abstract excerpt

BACKGROUND: We have previously shown that the slow Wallerian degeneration mutation, whilst delaying axonal degeneration after optic nerve crush, does not protect retinal ganglion cell (RGC) bodies in adult rats. To test the effects of a combination approach protecting both axons and cell bodies we performed combined optic nerve crush and lens injury, which results in both enhanced RGC survival as well as axon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to LIM-Homeodomain Proteins

Share to Nerve Regeneration

Share to Neuroglia

Share to Optic Nerve Diseases

Share to Rats, Transgenic

Share to Retinal Ganglion Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 22672534
DOI: 10.1186/1471-2202-13-56
PMCID: PMC3404964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury.PMID 22672534Read ↗

Zebrafish optic nerve injury results in systemic retinal ganglion cell dedifferentiationSemantic proximity Read ↗

Differential Susceptibility of Rat Retinal Ganglion Cells Following Optic Nerve CrushSemantic proximity Read ↗

Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush.Semantic proximity Read ↗

MEF2 transcription factors differentially contribute to retinal ganglion cell loss after optic nerve injury.Semantic proximity Read ↗

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cellsSemantic proximity Read ↗

Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegenerationSemantic proximity Read ↗

Pou4f1 and pou4f2 are dispensable for the long-term survival of adult retinal ganglion cells in mice.Semantic proximity Read ↗

Transection of dysmyelinated optic nerve axons in adult rats lacking myelin basic protein.Semantic proximity Read ↗

The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.Semantic proximity Read ↗

Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucomaSemantic proximity Read ↗

Retinal Ganglion Cells Downregulate Gene Expression and Lose Their Axons within the Optic Nerve Head in a Mouse Glaucoma ModelSemantic proximity Read ↗

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.