Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during Wallerian degeneration.

Molecular and cellular neurosciences - 1 Nov 2003

De Susna, Trigueros Marcelino Avilés, Kalyvas Athena, David Samuel

Abstract excerpt

Phospholipase A(2) (PLA(2)) hydrolyzes phosphatidylcholine to lysophosphatidylcholine and arachidonic acid. The former can induce myelin breakdown and the latter, via eicosanoids, can stimulate inflammatory responses. Immunohistochemical analysis of secreted (sPLA(2)) and cytosolic (cPLA(2)) forms of the enzyme was assessed in the injured adult rat sciatic and optic nerves. sPLA(2) and cPLA(2) are expressed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonic Acids
Share to Axons
Share to Microscopy, Electron

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myelin Sheath

Share to Phagocytosis

Share to Phospholipases A

Share to Phospholipases A2

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 14664823
DOI: 10.1016/s1044-7431(03)00241-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during Wallerian degeneration.PMID 14664823Read ↗

Peripheral nerve injury induces Schwann cells to express two macrophage phenotypes: phagocytosis and the galactose-specific lectin MAC-2.Semantic proximity Read ↗

The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation.Semantic proximity Read ↗

Quantification of the mononuclear phagocyte response to Wallerian degeneration of the optic nerve.Semantic proximity Read ↗

Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's diseaseSemantic proximity Read ↗

Impairment of toll-like receptors 2 and 4 leads to compensatory mechanisms after sciatic nerve axotomy.Semantic proximity Read ↗

Regulation of type V phospholipase A<sub>2</sub> expression and function by proinflammatory stimuliSemantic proximity Read ↗

Lysosomal phospholipase A2 and phospholipidosis.Semantic proximity Read ↗

Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.Semantic proximity Read ↗

Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.Semantic proximity Read ↗

Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice.Semantic proximity Read ↗

Ammodytoxins efficiently release arachidonic acid and induce apoptosis in a motoneuronal cell line in an enzymatic activity-dependent manner.Semantic proximity Read ↗

Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.