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Article

Targeted disruption of Hoxd-10 affects mouse hindlimb development.

Development (Cambridge, England) - 1 Nov 1997

Carpenter E M, Goddard J M, Davis A P, Nguyen T P, Capecchi M R

Abstract excerpt

Targeted disruption of the Hoxd-10 gene, a 5' member of the mouse HoxD linkage group, produces mice with hindlimb-specific defects in gait and adduction. To determine the underlying causes of this locomotor defect, mutant mice were examined for skeletal, muscular and neural abnormalities. Mutant mice exhibit alterations in the vertebral column and in the bones of the hindlimb. Sacral vertebrae beginning at the...

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PMID: 9409668
DOI: 10.1242/dev.124.22.4505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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