Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?

doi:10.1002/(SICI)1097-0177(199809)213:1<1::AID-AJA1>3.0.CO;2-L

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Article

Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 1998

Beckers J, Duboule D

Abstract excerpt

Extensive sequencing in the HoxD complex of several vertebrate species has revealed a set of conserved DNA sequences interspersed between neighboring Hox genes. Their high degree of conservation strongly suggested that they are used for regulatory purposes, a hypothesis that was largely confirmed...

Topics

Alleles
Animals
Conserved Sequence
Gene Expression Regulation, Developmental
Gene Targeting
Homeodomain Proteins
Mice
Mice, Inbred C57BL
Mice, Transgenic
Morphogenesis
Phenotype
Transcription Factors
Urogenital System

Source

Open in PubMed

Identifiers

PMID: 9733096
DOI: 10.1002/(SICI)1097-0177(199809)213:1<1::AID-AJA1>3.0.CO;2-L

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9733096-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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