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Article

Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 1998

Beckers J, Duboule D

Abstract excerpt

Extensive sequencing in the HoxD complex of several vertebrate species has revealed a set of conserved DNA sequences interspersed between neighboring Hox genes. Their high degree of conservation strongly suggested that they are used for regulatory purposes, a hypothesis that was largely confirmed by using "classical transgenesis" or in vivo mutagenesis through the embryonic stem (ES) cell technology. Here, we...

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PMID: 9733096
DOI: 10.1002/(SICI)1097-0177(199809)213:1<1::AID-AJA1>3.0.CO;2-L

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