Article
Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.
Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995
McGlynn K A, Rosvold E A, Lustbader E D, Hu Y, Clapper M L, Zhou T, Wild C P, Xia X L, Baffoe-Bonnie A, Ofori-Adjei D
Abstract excerpt
Aflatoxin B1 (AFB1) has been postulated to be a hepatocarcinogen in humans, possibly by causing p53 mutations at codon 249. AFB1 is metabolized via the phase I and II detoxification pathways; hence, genetic variation at those loci may predict susceptibility to the effects of AFB1. To test this hy...
Topics
- Aflatoxin B1
- Carcinoma, Hepatocellular
- Case-Control Studies
- China
- Codon
- DNA
- Epoxide Hydrolases
- Genes, p53
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Glutathione Transferase
- Hepatitis B Surface Antigens