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Article

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

McGlynn K A, Rosvold E A, Lustbader E D, Hu Y, Clapper M L, Zhou T, Wild C P, Xia X L, Baffoe-Bonnie A, Ofori-Adjei D

Abstract excerpt

Aflatoxin B1 (AFB1) has been postulated to be a hepatocarcinogen in humans, possibly by causing p53 mutations at codon 249. AFB1 is metabolized via the phase I and II detoxification pathways; hence, genetic variation at those loci may predict susceptibility to the effects of AFB1. To test this hypothesis, genetic variation in two AFB1 detoxification genes, epoxide hydrolase (EPHX) and glutathione S-transferase M1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 7892276
DOI: 10.1073/pnas.92.6.2384
PMCID: PMC42488

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1.PMID 7892276Read ↗

AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249.Semantic proximity Read ↗

Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis.Semantic proximity Read ↗

Genome-wide association study of the TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and infection with hepatitis B virusSemantic proximity Read ↗

When less is more: The association between the expression of polymorphic CYPs and AFB1-induced HCC.Semantic proximity Read ↗

Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma.Semantic proximity Read ↗

Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure?Semantic proximity Read ↗

Genome-wide association study of TP53 R249S mutation in hepatocellular carcinoma with aflatoxin B1 exposure and hepatitis B virus infection in GuangxiSemantic proximity Read ↗

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The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis.Semantic proximity Read ↗

Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case-control study.Semantic proximity Read ↗

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