Article
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
The Journal of biological chemistry - 17 Mar 1995
Haass C, Capell A, Citron M, Teplow D B, Selkoe D J
Abstract excerpt
We analyzed the effect of the vacuolar H(+)-ATPase inhibitor bafilomycin A1 (bafA1) on the processing of beta-amyloid precursor protein (beta APP). In kidney 293 cells stably transfected with the wild-type beta APP cDNA, bafA1 caused a stabilization of mature beta APP and its 10-kDa COOH-terminal...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Anti-Bacterial Agents
- Cell Line
- Cell Membrane
- Cells, Cultured
- DNA, Complementary
- Fibroblasts
- Humans
- Kidney
- Kinetics
- Macrolides
- Methionine
- Molecular Sequence Data
- Mutation
- Phenylalanine