Article
Subunit a of the yeast V-ATPase participates in binding of bafilomycin.
The Journal of biological chemistry - 9 Dec 2005
Wang Yanru, Inoue Takao, Forgac Michael
Abstract excerpt
Bafilomycin and concanamycin are potent and highly specific inhibitors of the vacuolar (H(+))-ATPases (V-ATPases), typically inhibiting at nanomolar concentrations. Previous studies have shown that subunit c of the integral V(0) domain participates in bafilomycin binding, and that this site resembles the oligomycin binding site of the F-ATPase (Bowman, B. J., and Bowman, E. J. (2002) J. Biol. Chem. 277,...
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