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Article

A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo.

Nature - 9 Aug 1990

Hülskamp M, Pfeifle C, Tautz D

Abstract excerpt

Segmentation of the Drosophila embryo depends on a hierarchy of interactions among the maternal and zygotic genes in the early embryo. The anterior region is organized maternally by the bicoid (bcd) gene product, which forms a concentration gradient in the anterior half of the embryo. The gap genes are also involved in establishing the body plan, with hunchback (hb) being expressed both maternally and...

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PMID: 2377231
DOI: 10.1038/346577a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A morphogenetic gradient of hunchback protein organizes the expression of the gap genes Krüppel and knirps in the early Drosophila embryo.PMID 2377231Read ↗

Autonomous concentration-dependent activation and repression of Krüppel by hunchback in the Drosophila embryo.Semantic proximity Read ↗

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Delimiting the conserved features of hunchback function for the trunk organization of insects.Semantic proximity Read ↗

Mediation of Drosophila head development by gap-like segmentation genes.Semantic proximity Read ↗

Gene expression mediated by cis-acting sequences of the Krüppel gene in response to the Drosophila morphogens bicoid and hunchback.Semantic proximity Read ↗

Target sequences for hunchback in a control region conferring Ultrabithorax expression boundaries.Semantic proximity Read ↗

hunchback is required for suppression of abdominal identity, and for proper germband growth and segmentation in the intermediate germband insect Oncopeltus fasciatus.Semantic proximity Read ↗

Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the Drosophila embryo.Semantic proximity Read ↗

Krüppel acts as a gap gene regulating expression of hunchback and even-skipped in the intermediate germ cricket Gryllus bimaculatus.Semantic proximity Read ↗

Differential regulation of target genes by different alleles of the segmentation gene hunchback in Drosophila.Semantic proximity Read ↗

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