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Article

Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos.

Nature cell biology - 1 Nov 1999

Asaoka-Taguchi M, Yamada M, Nakamura A, Hanyu K, Kobayashi S

Abstract excerpt

The maternal RNA-binding proteins Pumilio (Pum) and Nanos (Nos) act together to specify the abdomen in Drosophila embryos. Both proteins later accumulate in pole cells, the germline progenitors. Nos is required for pole cells to differentiate into functional germline. Here we show that Pum is also essential for germline development in embryos. First, a mutation in pum causes a defect in pole-cell migration into...

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Identifiers

PMID: 10559987
DOI: 10.1038/15666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos.PMID 10559987Read ↗

Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells.Semantic proximity Read ↗

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The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and embryogenesis.Semantic proximity Read ↗

Germ cell-autonomous Wunen2 is required for germline development in Drosophila embryos.Semantic proximity Read ↗

Analysis of RNA Interference Lines Identifies New Functions of Maternally-Expressed Genes Involved in Embryonic Patterning in Drosophila melanogaster.Semantic proximity Read ↗

A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary.Semantic proximity Read ↗

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An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline1Semantic proximity Read ↗

No significant regulation of bicoid mRNA by Pumilio or Nanos in the early Drosophila embryo.Semantic proximity Read ↗

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