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Article

High prevalence but low clinical impact of acyclovir-resistant herpes simplex virus type 1 infections in patients with hematologic disorders.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 1 Feb 2026

Chen Chih-Hao, Chen Ling-Ling, Su Mei-Chi, Lin Hsiu-Hsien, Ho Mao-Wang, Lin Cheng-Wen, Hsueh Po-Ren

Abstract excerpt

BACKGROUND/PURPOSE: Herpes simplex virus type 1 (HSV-1) is highly prevalent in immunocompromised patients. Due to the recurrent nature of HSV-1 infection, frequent exposure to antiviral agents raises concerns about drug resistance. This study aimed to investigate antiviral-resistant profiles of HSV-1 and discuss the clinical impact of acyclovir-resistant (ACV-R) compared to acyclovir-susceptible (ACV-S) HSV-1...

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Identifiers

PMID: 40817015
DOI: 10.1016/j.jmii.2025.08.001

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