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Article

Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 1997

Marks D I, Kurz B W, Link M P, Ng E, Shuster J J, Lauer S J, Carroll D, Brodsky I, Haines D S

Abstract excerpt

PURPOSE: To determine whether potential alteration in p53 function through p53 gene mutation or mdm-2 overexpression correlates with early treatment failure in childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Diagnostic marrow samples from 34 children were analyzed for p53 gene alterations by western blot and SSCP/DNA sequence analysis and for mdm-2 overexpression by western blot analysis....

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PMID: 9060559
DOI: 10.1200/JCO.1997.15.3.1158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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