Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia.

doi:10.1200/JCO.1997.15.3.1158

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Article

Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 1997

Marks D I, Kurz B W, Link M P, Ng E, Shuster J J, Lauer S J, Carroll D, Brodsky I, Haines D S

Abstract excerpt

PURPOSE: To determine whether potential alteration in p53 function through p53 gene mutation or mdm-2 overexpression correlates with early treatment failure in childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Diagnostic marrow samples from 34 children were analyzed for p53 gene...

Topics

Child
Child, Preschool
Genes, p53
Humans
Mutation
Nuclear Proteins
Pilot Projects
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Treatment Failure
Tumor Suppressor Protein p53

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Identifiers

PMID: 9060559
DOI: 10.1200/JCO.1997.15.3.1158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9060559-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.