Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

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Article

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

Cancer research - 15 Jun 1993

Reifenberger G, Liu L, Ichimura K, Schmidt E E, Collins V P

Abstract excerpt

The MDM2 (murine double minute 2) gene has recently been shown to code for a cellular protein that can complex the p53 tumor suppressor gene product and inhibit its function. We studied a series of 157 primary brain tumors and report here that the MDM2 gene is amplified and overexpressed in 8-10%...

Topics

Astrocytoma
Base Sequence
Chromosome Banding
Chromosomes, Human, Pair 17
ErbB Receptors
Gene Amplification
Gene Rearrangement
Genes, p53
Glioma
Humans
Molecular Sequence Data
Mutation
Neoplasm Proteins
Nuclear Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
RNA, Messenger
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8504413

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8504413-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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