Article
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.
Cancer research - 15 Jun 1993
Reifenberger G, Liu L, Ichimura K, Schmidt E E, Collins V P
Abstract excerpt
The MDM2 (murine double minute 2) gene has recently been shown to code for a cellular protein that can complex the p53 tumor suppressor gene product and inhibit its function. We studied a series of 157 primary brain tumors and report here that the MDM2 gene is amplified and overexpressed in 8-10% of glioblastomas and anaplastic astrocytomas. Thus, MDM2 represents the second most frequently amplified gene after...
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