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Article

The human MDM-2 oncogene is overexpressed in leukemias

1993-11-01

Abstract excerpt

Abstract The human homologue of the mouse double minute 2 (MDM-2) gene codes for a cellular protein that forms a complex with the mutant and wild-type p53 protein and modulates its trans-activation activity. Overexpression of the MDM-2 gene in cells increases their tumorigenic potential and overcomes the growth-suppressive activity of p53. Previous reports have shown that the MDM-2 gene is amplified in approximate...

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Literature Corpus work
0d982c1e-1ee7-520f-b252-6cf6bd0f9317
DOI
10.1182/blood.v82.9.2617.2617
Open publication

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The human MDM-2 oncogene is overexpressed in leukemiasDOI 10.1182/blood.v82.9.2617.2617
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