Article
CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.
The American journal of pathology - 1 Mar 2001
Kim K S, Denton M D, Chandraker A, Knoflach A, Milord R, Waaga A M, Turka L A, Russell M E, Peach R, Sayegh M H
Abstract excerpt
Provision of adequate T cell costimulation is critical for the development of acute and chronic allograft rejection. We have previously reported that early blockade of CD28-B7 T cell costimulation prevents the development of graft arteriosclerosis, in the LEW into F344 rat cardiac transplant model. In this study, we used the same model to examine the requirement for CD28-B7-mediated T cell costimulation in the...
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