Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.

doi:10.1074/jbc.273.5.2692

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Article

Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.

The Journal of biological chemistry - 30 Jan 1998

Iyer S, Woo J, Cornejo M C, Gao L, McCoubrey W, Maines M, Buelow R

Abstract excerpt

This is the first report on peptidic inhibitors of heme oxygenase. Such peptides were originally developed from the immunomodulatory peptide 2702.75-84 which corresponds to amino acid residues 75 to 84 of the alpha1-helix of HLA-B2702 (2702.75-84) and has been shown to be immunosuppressive in vit...

Topics

Adjuvants, Immunologic
Animals
Carrier Proteins
Chromatography, Affinity
Enzyme Induction
Glutamic Acid
HLA-B Antigens
Heme Oxygenase (Decyclizing)
Immunosuppressive Agents
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mutation
Peptide Fragments
Protoporphyrins
Valine

Source

Open in PubMed

Identifiers

PMID: 9446574
DOI: 10.1074/jbc.273.5.2692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9446574-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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