Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody.

doi:10.1097/00007890-199212000-00003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody.

Transplantation - 1 Dec 1992

Lehmann M, Sternkopf F, Metz F, Brock J, Döcke W D, Plantikow A, Kuttler B, Hahn H J, Ringel B, Volk H D

Abstract excerpt

The new monoclonal antirat CD4 antibody RIB 5/2, which detects another epitope than those covered by W3/25 and MRC OX35, was tested for its immunosuppressive potency following skin allografting by using strain combinations with different genetic barriers in the MHC and genetic low- or high-responder background. High-dose and long-term therapy of the grafted rats led to a significant delay of the acute rejection...

Topics

Animals
Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Antibody Formation
CD4 Antigens
Epitopes
Female
Flow Cytometry
Graft Survival
Immunoglobulin Idiotypes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Rats, Inbred Lew

Rats, Inbred WF

Skin Transplantation

Time Factors

Transplantation, Homologous

Source

Open in PubMed

Identifiers

PMID: 1281565
DOI: 10.1097/00007890-199212000-00003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1281565-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of long-term survival of rat skin allografts by a novel, highly efficient anti-CD4 monoclonal antibody.PMID 1281565Read ↗

Fully and long-term xenogeneic hematopoietic chimeras created in poorly concordant rat-mouse combinations: expression of hereditary donor characteristics.Semantic proximity Read ↗

Alloreactive CD4 T lymphocytes responsible for acute and chronic graft‐versus‐host disease are contained within the CD45RC<sup>high</sup> but not the CD45RC<sup>low</sup> subsetSemantic proximity Read ↗

The rat RT1-A1c MHC molecule is a xenogeneic ligand recognized by the mouse activating Ly-49W and inhibitory Ly-49G receptors.Semantic proximity Read ↗

Experimental melanin-induced uveitis in the Fischer 344 rat is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate.Semantic proximity Read ↗

Constitutive expression of a CD44 variant isoform on T cells facilitates regaining of immunocompetence in allogeneic bone marrow transplantation.Semantic proximity Read ↗

Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains.Semantic proximity Read ↗

A comprehensive flow-cytometric analysis of graft infiltrating lymphocytes, draining lymph nodes and serum during the rejection phase in a fully allogeneic rat cornea transplant model.Semantic proximity Read ↗

Immunomodulatory Effects of Different Cellular Therapies of Bone Marrow Origin on Chimerism Induction and Maintenance Across MHC Barriers in a Face Allotransplantation Model.Semantic proximity Read ↗

Cytotoxic T-cell elimination during anti-CD4-induced rat liver acceptance and rapid replacement of functional graft antigen-presenting cells.Semantic proximity Read ↗

Experimental autoimmune myasthenia gravis may occur in the context of a polarized Th1- or Th2-type immune response in rats.Semantic proximity Read ↗

Typing of inbred strains for RT3 and mapping of this antigenic system to linkage group X of the rat.Semantic proximity Read ↗

Prolongation of allogeneic heart graft survival in rats by administration of a peptide (a.a. 75-84) from the alpha 1 helix of the first domain of HLA-B7 01.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.