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Article

Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance.

Transplantation - 27 Sept 2007

Fan Kexing, Wang Hao, Wei Huafeng, Zhou Qian, Kou Geng, Hou Sheng, Qian Weizhu, Dai Jianxin, Li Bohua, Zhang Yanyun, Zhu Tongyu, Guo Yajun

Abstract excerpt

BACKGROUND: Previous studies have shown that blockade of LIGHT, a T-cell costimulatory molecule belonging to the tumor necrosis factor (TNF) superfamily, by soluble lymphotoxin beta receptor-Ig (LTbetaR-Ig) inhibited the development of graft-versus-host disease. The cardiac allografts were significantly prolonged in LIGHT deficient mice. No data are yet available regarding the role of the LIGHT/HVEM pathway in...

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Source

Identifiers

PMID: 17893608
DOI: 10.1097/01.tp.0000280545.14489.df

Genes

CTLA4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance.PMID 17893608Read ↗

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