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Article

Functional heterogeneity and heritability in CHO cell populations

25 Jul 2012

Abstract excerpt

In this study, we address the hypothesis that it is possible to exploit genetic/functional variation in parental Chinese hamster ovary (CHO) cell populations to isolate clonal derivatives that exhibit superior, heritable attributes for biomanufacturing--new parental cell lines which are inherently more "fit for purpose." One-hundred and ninety-nine CHOK1SV clones were isolated from a donor CHOK1SV parental...

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PMID: 22833427
DOI: 10.1002/bit.24621

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