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Article

Glutathione S-transferase (GSTM1 and GSTT1)-dependent risk for colorectal cancer.

Anticancer research - 1 Jan 2000

Laso N, Lafuente M J, Mas S, Trias M, Ascaso C, Molina R, Ballesta A, Rodriguez F, Lafuente A

Abstract excerpt

BACKGROUND: The deleted GSTT1 and GSTM1 genotypes (null genotypes) resulting in loss of transferase activity are found in 10-20% and 50-60% of the population, respectively. PATIENTS AND METHODS: The GSTT1- and GSTM1-dependent risk for sporadic colorectal cancer (CRC) was studied in 247 incident CRC cases and 296 hospital-based controls. RESULTS: The GSTT1-null genotype was found to be 1.5 times more prevalent in...

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Identifiers

PMID: 12530094

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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