Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of compartment deacidification on the targeting of membrane and soluble proteins to the vacuole in yeast.

Journal of cell science - 1 Oct 1994

Morano K A, Klionsky D J

Abstract excerpt

Lysosomal/vacuolar protein targeting is dependent on compartment acidification. In yeast, sorting of soluble vacuolar proteins such as carboxypeptidase Y is sensitive to acute changes in vacuolar pH. In contrast, the vacuolar membrane protein alkaline phosphatase is missorted only under conditions of chronic deacidification. We have undertaken a temporal analysis to define further the relationship between...

Topics

Acids
Adenosine Triphosphatases
Base Sequence
Cell Compartmentation
Fungal Proteins
Hydrogen-Ion Concentration
Membrane Proteins
Molecular Sequence Data
Mutation
Phenotype
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Solubility

Vacuoles

Source

Identifiers

PMID: 7876349
DOI: 10.1242/jcs.107.10.2813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7876349-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of compartment deacidification on the targeting of membrane and soluble proteins to the vacuole in yeast.PMID 7876349Read ↗

Mutations in the yeast vacuolar ATPase result in the mislocalization of vacuolar proteins.Semantic proximity Read ↗

A yeast lysosomal biogenesis map uncovers the cargo spectrum of lysosomal protein targeting pathwaysSemantic proximity Read ↗

Lysosomal proteomics and disease.Semantic proximity Read ↗

A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology.Semantic proximity Read ↗

Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPase.Semantic proximity Read ↗

Peroxisome degradation in Saccharomyces cerevisiae is dependent on machinery of macroautophagy and the Cvt pathway.Semantic proximity Read ↗

Lysosomal and vacuolar sorting: not so different after all!Semantic proximity Read ↗

PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation.Semantic proximity Read ↗

Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome.Semantic proximity Read ↗

Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism.Semantic proximity Read ↗

A new class of lysosomal/vacuolar protein sorting signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.