Article
Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.
The Biochemical journal - 15 Jun 2004
Faergeman Nils J, Feddersen Søren, Christiansen Janne K, Larsen Morten K, Schneiter Roger, Ungermann Christian, Mutenda Kudzai, Roepstorff Peter, Knudsen Jens
Abstract excerpt
In the present study, we show that depletion of acyl-CoA-binding protein, Acb1p, in yeast affects ceramide levels, protein trafficking, vacuole fusion and structure. Vacuoles in Acb1p-depleted cells are multi-lobed, contain significantly less of the SNAREs (soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptors) Nyv1p, Vam3p and Vti1p, and are unable to fuse in vitro. Mass spectrometric...
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