Article
Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 1995
Madeddu P, Parpaglia P P, Demontis M P, Varoni M V, Fattaccio M C, Anania V, Glorioso N
Abstract excerpt
We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats...
Topics
- Aging
- Animals
- Animals, Newborn
- Blood Pressure
- Bradykinin
- Bradykinin Receptor Antagonists
- Cardiovascular Physiological Phenomena
- Cardiovascular System
- Female
- Male
- Phenotype
- Pregnancy
- Prenatal Exposure Delayed Effects
- Rats
- Receptors, Bradykinin
- Sodium