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Article

Early blockade of bradykinin B2-receptors alters the adult cardiovascular phenotype in rats.

Hypertension (Dallas, Tex. : 1979) - 1 Mar 1995

Madeddu P, Parpaglia P P, Demontis M P, Varoni M V, Fattaccio M C, Anania V, Glorioso N

Abstract excerpt

We evaluated whether long-term inhibition of bradykinin B2-receptors by the long-acting antagonist Hoe 140 (D-Arg,[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin) affects the blood pressure of normotensive rats. Neither Hoe 140 (at 75 nmol/d for 8 weeks) nor its vehicle altered systolic pressure of adult rats on a normal or high sodium intake. In further experiments, pairs of Hoe 140-treated rats were mated and their...

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Identifiers

PMID: 7875772
DOI: 10.1161/01.hyp.25.3.453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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