Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation.

Bone - 1 Jan 2000

Cassella J P, Pereira R, Khillan J S, Prockop D J, Garrington N, Ali S Y

Abstract excerpt

A line of transgenic mice have been investigated that expressed moderate levels of an internally deleted human gene for the pro alpha (I) chain of type I procollagen. These mice expressed the gene at approximately 50% that of the endogenous gene. The gene construct was modeled after a sporadic in-frame deletion of the human gene that produced a lethal variant of osteogenesis imperfecta by causing biosynthesis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Disease Models, Animal
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Microscopy, Electron

Share to Models, Genetic

Share to Mutation

Source

Identifiers

PMID: 7873289
DOI: 10.1016/8756-3282(94)90308-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation.PMID 7873289Read ↗

Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.Semantic proximity Read ↗

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model.Semantic proximity Read ↗

A microanalytical study of bone mineral in a transgenic mouse model for brittle bone disease.Semantic proximity Read ↗

Morphological and mechanical characterization of bone phenotypes in the Amish G610C murine model of osteogenesis imperfecta.Semantic proximity Read ↗

Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta.Semantic proximity Read ↗

A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.Semantic proximity Read ↗

A human COL2A1 gene with an Arg519Cys mutation causes osteochondrodysplasia in transgenic mice.Semantic proximity Read ↗

Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen.Semantic proximity Read ↗

Comparison of bone tissue properties in mouse models with collagenous and non-collagenous genetic mutations using FTIRI.Semantic proximity Read ↗

An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.Semantic proximity Read ↗

Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta.Semantic proximity Read ↗

Retarded skeletal development in transgenic mice with a type II collagen mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.