Article
An ultrastructural, microanalytical, and spectroscopic study of bone from a transgenic mouse with a COL1.A1 pro-alpha-1 mutation.
Bone - 1 Jan 2000
Cassella J P, Pereira R, Khillan J S, Prockop D J, Garrington N, Ali S Y
Abstract excerpt
A line of transgenic mice have been investigated that expressed moderate levels of an internally deleted human gene for the pro alpha (I) chain of type I procollagen. These mice expressed the gene at approximately 50% that of the endogenous gene. The gene construct was modeled after a sporadic in...
Topics
- Aging
- Animals
- Bone Density
- Calcium
- Disease Models, Animal
- Electron Probe Microanalysis
- Femur
- Gene Expression Regulation
- Growth Plate
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Models, Genetic
- Mutation
- Osteoblasts
- Osteogenesis Imperfecta
- Phosphorus
- Procollagen