Article
Transgenic mice expressing a partially deleted gene for type I procollagen (COL1A1). A breeding line with a phenotype of spontaneous fractures and decreased bone collagen and mineral.
The Journal of clinical investigation - 1 Feb 1993
Pereira R, Khillan J S, Helminen H J, Hume E L, Prockop D J
Abstract excerpt
A line of transgenic mice was prepared that expressed moderate levels of an internally deleted human gene for the pro alpha 1(I) chain of type I procollagen. The gene construct was modeled after a sporadic in-frame deletion of the human gene that produced a lethal variant of osteogenesis imperfec...
Topics
- Animals
- Base Sequence
- Bone Density
- Bone and Bones
- Collagen
- Disease Models, Animal
- Fractures, Spontaneous
- Gene Deletion
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype
- Procollagen