Article
Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors.
Molecular brain - 13 Aug 2013
Han Lu, Campanucci Verónica A, Cooke James, Salter Michael W
Abstract excerpt
BACKGROUND: NMDA receptors are ligand-gated ion channels with essential roles in glutamatergic synaptic transmission and plasticity in the CNS. As co-receptors for glutamate and glycine, gating of the NMDA receptor/channel pore requires agonist binding to the glycine sites, as well as to the glutamate sites, on the ligand-binding domains of the receptor. In addition to channel gating, glycine has been found to...
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