Article
kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire.
The Journal of experimental medicine - 1 Mar 1995
Giachino C, Padovan E, Lanzavecchia A
Abstract excerpt
It is a common notion that mature B lymphocytes express either kappa or lambda light (L) chains, although the mechanism that leads to such isotypic exclusion is still debated. We have investigated the extent of L chain isotypic exclusion in normal human peripheral blood B lymphocytes. By three-co...
Topics
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Humans
- Immunoglobulin M
- Immunoglobulin kappa-Chains
- Immunoglobulin lambda-Chains
- Molecular Sequence Data
- Mutation